Accuracy and clinical feasibility of 3D‑myocardial thickness map measured by cardiac computed tomogram
10.1186/s42444-020-00020-w
- Author:
Oh‑Seok KWON
1
;
Jisu LEE
;
Sehwan LIM
;
Je‑Wook PARK
;
Hee‑Jin HAN
;
So‑Hyun YANG
;
Inseok HWANG
;
Hee Tae YU
;
Tae‑Hoon KIM
;
Jae‑Sun UHM
;
Boyoung JOUNG
;
Moon‑Hyoung LEE
;
Hui‑Nam PAK
Author Information
1. Division of Cardiology, Department of Internal Medicine, Yonsei University Health System, 50‑1 Yonsei‑ro, Seodaemun‑gu, Seoul 03722, Republic of Korea
- Publication Type:RESEARCH
- From:International Journal of Arrhythmia
2020;21(3):e12-
- CountryRepublic of Korea
- Language:0
-
Abstract:
Background:Although myocardial thickness is an important variable for therapeutic catheter ablation of cardiac arrhythmias, quantification of wall thickness has been overlooked. We developed a software (AMBER) that measures 3D-myocardial thickness using a cardiac computed tomogram (CT) image, verified its accuracy, and tested its clinical feasibility.
Methods:We generated 3D-thickness maps by calculating wall thickness (WT) from the CT images of 120 patients’ hearts and a 3D-phantom model (PhM). The initial vector field of the Laplace equation was oriented to calculate WT with the field lines derived from the 3D mesh. We demonstrate the robustness of the Laplace WT algorithm by comparing with the real thickness of 3D-PhM, echocardiographically measured left ventricular (LV) WT, and regional left atrial (LA) WT reported from previous studies. We conducted a pilot case of catheter ablation for atrial fibrillation (AF) utilizing real-time LAWT map-guided radiofrequency (RF) energy titration.
Results:AMBER 3D-WT had excellent correlations with the real thickness of the PhM (R = 0.968, p < 0.001) and echocardiographically measured LVWT in 10 patients (R = 0.656, p = 0.007). AMBER 3D-LAWT (n = 120) showed a relatively good match with 12 previously reported regional LAWT. We successfully conducted pilot AF ablation utilizing AMBER 3D-LAWT map-guided real-time RF energy titration.
Conclusion:We developed and verified an AMBER 3D-cardiac thickness map measured by cardiac CT images for LAWT and LVWT, and tested its feasibility for RF energy titration during clinical catheter ablation.
