The Roles of CCR7 for the Homing of Memory CD8+ T Cells into Their Survival Niches
- Author:
Hanbyeul CHOI
1
;
Heonju SONG
;
Yong Woo JUNG
Author Information
- Publication Type:Review Article
- From:Immune Network 2020;20(3):e20-
- CountryRepublic of Korea
- Language:0
- Abstract: Memory CD8+ T cells in the immune system are responsible for the removal of external Ags for a long period of time to protect against re-infection. Naïve to memory CD8+ T cell differentiation and memory CD8+ T cell maintenance require many different factors including local environmental factors. Thus, it has been suggested that the migration of memory CD8+ T cells into specific microenvironments alters their longevity and functions. In this review, we have summarized the subsets of memory CD8+ T cells based on their migratory capacities and described the niche hypothesis for their survival. In addition, the basic roles of CCR7 in conjunction with the migration of memory CD8+ T cells and recent understandings of their survival niches have been introduced. Finally, the applications of altering CCR7 signaling have been discussed.
