Population pharmacokinetics and inter-laboratory variability of sildenafil and its metabolite after oral administration in Korean healthy male volunteers.
10.12793/tcp.2016.24.2.105
- Author:
Sunil YOUN
1
;
Wan Su PARK
;
Gab Jin PARK
;
Doo Yeon JANG
;
Soo Hyeon BAE
;
Seunghoon HAN
;
Dong Seok YIM
Author Information
1. Department of Clinical Pharmacology and Therapeutics, Seoul St. Mary's Hospital, PIPET (Pharmacometrics Institute for Practical Education and Training), College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea. waystolove@catholic.ac.kr
- Publication Type:Original Article
- Keywords:
Sildenafil;
Population pharmacokinetics;
Koreans;
Mixed-effects model (MEM);
NONMEM
- MeSH:
Absorption;
Administration, Oral*;
Asian Continental Ancestry Group;
Dataset;
Healthy Volunteers;
Humans;
Male*;
Pharmacokinetics*;
Plasma;
Sildenafil Citrate*;
Volunteers*
- From:Translational and Clinical Pharmacology
2016;24(2):105-110
- CountryRepublic of Korea
- Language:English
-
Abstract:
This study was to clarify population pharmacokinetics (PK) of sildenafil and its metabolite, N-desmethyl sildenafil (NDS) in Korean healthy male population using a pooled data from multiple clinical trials in consideration of inter-institution and inter-laboratory difference. A population PK analysis was performed with data of 243 healthy volunteers from five single-center (4 centers) comparative PK trials. The dataset included 7,376 sildenafil and NDS concentration (3,688 for each analyte) observed during 24 hours after the single dose of original sildenafil (either 50 mg or 100 mg of Viagra®). The plasma concentration was assayed in two laboratories. Various model structure was tested and the final model was evaluated using visual predictive checks. Demographic and clinical variables were assessed as potential covariates for PK parameters. A one-compartment first-order elimination model with proportional error was selected for the dispositional characteristics of sildenafil, and two-compartment model was chosen for NDS. Three transit compartments with Erlang-type absorption for fast absorption pathway and one compartment for slow absorption pathway constructed overall absorption model. The first-pass effect was rejected since it does not improve the model. The difference of NDS level by the bioanalysis laboratory was selected as the only covariate. Even though a direct comparison was difficult, the general trend in PK of sildenafil and NDS for Korean healthy male was considered similar to that of the other populations reported previously. It is recommended that the laboratory effect should be explored and evaluated when dataset is built using results from several laboratories.
