The effects of UVA and UVB on proliferation and melanization in SK 23 melanoma cell lines.
- Author:
Mu Hyoung LEE
;
Jin Hwan KIM
;
Choong Rim HAW
- Publication Type:Original Article
- Keywords:
Melanization;
UVA;
UVB
- MeSH:
Cell Count;
Cell Line*;
Humans;
Melanins;
Melanocytes;
Melanoma*;
Pigmentation;
Research Personnel;
Tanning;
Triacetoneamine-N-Oxyl
- From:Korean Journal of Dermatology
1993;31(5):732-737
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: The visible cutaneous pigmentary response to ultraviolet A(UVA) is immediate, whereas ultraviolet B(UVB)-induced pigmentation appears after a delay of several days. However, some investigators reported that UVA also can induce delayed taniing. OBJECTIVE: In order to determine whether the pigmentation induceil by UVA irradiation is accompanied by melanocytes responses which are the same or different from those following a UVB-indueed tan, we irraiated malignant melanoma cells to UVA or UVB. METHOD: On the 7th day after irradiation of UVA or UVB, we exa nined the cell counts and the melanin content of control and experimental groups. RESULTS: Although a dose of 10 J/cm decreased the number of manignant melanoma cells, there was no significant difference between the control and UVA-exposure griiups. But there was a significant decrease after UVB-exposun. UVB-exposure groups showed a significant increase of melanin cortent. A dose of 10 J/cm of UVA also induced a significant increase of melanin content. CONCLUSIONS: The data suggest that UVA at a clinically relevant dose has a significant effect on human melanocytes. So, UVA very likely plays a role in the increased, melanization associated with delayed tanning.
