Patterns in renal diseases diagnosed by kidney biopsy: A single-center experience
- Author:
Taehoon YIM
1
;
Sang-Un KIM
;
Sangmi PARK
;
Jeong-Hoon LIM
;
Hee-Yeon JUNG
;
Jang-Hee CHO
;
Chan-Duck KIM
;
Yong-Lim KIM
;
Man-Hoon HAN
;
Yong-Jin KIM
;
Ji-Young CHOI
;
Sun-Hee PARK
Author Information
- Publication Type:Original Article
- From:Kidney Research and Clinical Practice 2020;39(1):60-69
- CountryRepublic of Korea
-
Abstract:
Background:The worldwide incidence of renal disease diagnosed by a kidney biopsy varies with age, race, sex, and region. Owing to a lack of studies and limited research resources for this disease in Korea, we investigated renal disease patterns by analyzing data from kidney biopsies performed over 13 years in a university-based teaching hospital in Korea.
Methods:Among 2,053 kidney biopsies performed from 2001 to 2013 at Kyungpook National University Hospital, 1,924 were retrospectively analyzed for histopathologic, demographic, and clinical data as well as laboratory results.
Results:Among the 1,924 studied kidney biopsies, 1,078 were males (56.0%) and the mean age was 37.7 ± 16.5 years. Asymptomatic urinary abnormalities were the most common clinical manifestation (62.5%). Immunoglobulin A nephropathy (IgAN) was the most common primary glomerular disease (37.4%), followed by minimal change disease (MCD), membranous nephropathy (MN), focal segmental glomerulonephritis and crescentic glomerulonephritis. Secondary glomerular diseases accounted for 10.3% of the total biopsies, with lupus nephritis being the most common (4.6%) followed by Henoch-Schönlein purpura nephritis and diabetic nephropathy. The most common cause of nephrotic syndrome was MCD (42.1%) followed by MN. Among patients seropositive for hepatitis B or C, IgAN (28.3% and 21.4%, respectively) was the most common cause.
Conclusion:IgAN and lupus nephritis were the most common primary and secondary glomerular diseases, respectively. Race, region, and practice patterns may affect renal disease patterns in different cohorts.
