Pathophysiologic and Therapeutic Perspectives Based on Thrombus Histology in Stroke
- Author:
Ji Hoe HEO
1
;
Hyo Suk NAM
;
Young Dae KIM
;
Jin Kyo CHOI
;
Byung Moon KIM
;
Dong Joon KIM
;
Il KWON
Author Information
- Publication Type:Review
- From:Journal of Stroke 2020;22(1):64-75
- CountryRepublic of Korea
- Abstract: Recent advances in endovascular thrombectomy have enabled the histopathologic analysis of fresh thrombi in patients with acute stroke. Histologic analysis has shown that the thrombus composition is very heterogeneous between patients. However, the distribution pattern of each thrombus component often differs between patients with cardiac thrombi and those with arterial thrombi, and the efficacy of endovascular thrombectomy is different according to the thrombus composition. Furthermore, the thrombus age is related to the efficacy of reperfusion therapy. Recent studies have shown that neutrophils and neutrophil extracellular traps contribute to thrombus formation and resistance to reperfusion therapy. Histologic features of thrombi in patients with stroke may provide some clues to stroke etiology, which is helpful for determining the strategy of stroke prevention. Research on thrombus may also be helpful for improving reperfusion therapy, including the development of new thrombolytic agents.
