Fibrostenotic strictures in Crohn’s disease
- Author:
Jun Hwan YOO
1
;
Stefan HOLUBAR
;
Florian RIEDER
Author Information
- Publication Type:Review
- From:Intestinal Research 2020;18(4):379-401
- CountryRepublic of Korea
- Language:English
- Abstract: The use of biologic agents including anti-tumor necrosis factor monoclonal antibodies followed by anti-integrins and anti-interleukins has drastically changed the treatment paradigm of Crohn’s disease (CD) by improving clinical symptoms and mucosal healing. However, up to 70% of CD patients still eventually undergo surgery mainly due to fibrostenotic strictures. There are no specific anti-fibrotic drugs yet. This review comprehensively addresses the mechanism, prediction, diagnosis and treatment of the fibrostenotic strictures in CD. We also introduce promising anti-fibrotic agents which may be available in the near future and summarize challenges in developing novel therapies to treat fibrostenotic strictures in CD.
