Can distinction between the renalcortex and outer medulla onultrasonography predict estimatedglomerular filtration rate in caninechronic kidney diseases?
- Author:
Siheon LEE
1
;
Sungkyun HONG
;
Seungji KIM
;
Dayoung OH
;
Sangkyung CHOEN
;
Mincheol CHOI
;
Junghee YOON
Author Information
- Publication Type:Original Article
- From:Journal of Veterinary Science 2020;21(4):e58-
- CountryRepublic of Korea
-
Abstract:
Background:Quantitative evaluation of renal cortical echogenicity (RCE) has been tried anddeveloped in human and veterinary medicine.
Objectives:The objective of this study was to propose a method for evaluating RCEquantitatively and intuitively, and to determine associations between ultrasonographic renalstructural distinction and estimated glomerular filtration rate (eGFR) in canine chronickidney disease (CKD).
Methods:Data were collected on 63 dogs, including 27 with normal kidney function and 36CKD patients. Symmetric dimethylarginine and creatinine concentrations were measuredfor calculating eGFR. RCE was evaluated as 3 grades on ultrasonography images accordingto the distinction between the renal cortex and outer medulla. The RCE grade of each kidneywas measured.
Results:There was a significant difference in eGFR between the group normal and CKD (p< 0.001). As mean of RCE grades (the mean values of each right and left kidney's RCE grade)increases, the proportion of group CKD among the patients in each grade increases (p <0.001). Also, severity of RCE (classified as "high" if any right or left kidney evaluated as RCEgrade 3, "low" otherwise) and eGFR is good indicator for predicting group CKD (p < 0.001).
Conclusions:The degree of distinction between the renal cortex and the outer medulla isclosely related to renal function including eGFR and the RCE grade defined in this study canbe used as a method of objectively evaluating RCE.
