High Cell-Free DNA Levels in Cerebrospinal Fluid Predict Leptomeningeal Seeding of Hematologic Malignancy
10.3988/jcn.2020.16.4.581
- Author:
Eun Young KIM
1
;
Soon-Tae LEE
;
Young-Sook KIM
;
Ja Min BYUN
;
Junshik HONG
;
Dong-Yeop SHIN
;
Youngil KOH
;
Inho KIM
Author Information
1. Department of Neurology, Seoul National University Hospital, Seoul, Korea
- Publication Type:ORIGINAL ARTICLE
- From:Journal of Clinical Neurology
2020;16(4):581-585
- CountryRepublic of Korea
- Language:0
-
Abstract:
Background:and Purpose: The main difficulty when diagnosing leptomeningeal metastases (LMSs) is the low sensitivity of cytology. Cancer cells release cell-free DNA (cfDNA) during proliferation and apoptosis, and so we analyzed the cfDNA level as a biomarker for LMSs in hematologic malignancy.
Methods:This study prospectively enrolled 20 patients with hematologic malignancy who underwent cerebrospinal fluid (CSF) analysis. LMS was diagnosed based on both CSF cytology and clinical findings.
Results:The CSF level of cfDNA was higher in patients with LMSs (108.17±84.84 ng/mL, mean±standard deviation) than in non-LMS patients (14.23±2.78 ng/mL). The sensitivity of cfDNA was higher than that of cytology (100% vs. 87%).
Conclusions:The cfDNA level in the CSF can be used as a supplemental marker for diagnosing LMS in hematologic malignancy patients.
