Alterations in Structural and Functional Connectivities in Patients with End-Stage Renal Disease
10.3988/jcn.2020.16.3.390
- Author:
Bong Soo PARK
1
;
Si Eun KIM
;
Ho-Joon LEE
;
Yang Wook KIM
;
Il Hwan KIM
;
Jin Han PARK
;
Si Hyung PARK
;
Yoo Jin LEE
;
Sol A SEO
;
Kang Min PARK
Author Information
1. Department of Internal Medicine, Haeundae Paik Hospital, Inje University College of Medicine, Busan, Korea.
- Publication Type:ORIGINAL ARTICLE
- From:Journal of Clinical Neurology
2020;16(3):390-400
- CountryRepublic of Korea
- Language:0
-
Abstract:
Background:and Purpose: The aim of this study was to evaluate the structural and functional connectivities of brain network using graph theoretical analysis in neurologically asymptomatic patients with end-stage renal disease (ESRD). We further investigated the prevalence of cognitive impairment (CI) in ESRD patients and analyzed the association between network measures of brain connectivity and cognitive function.
Methods:We prospectively enrolled 40 neurologically asymptomatic ESRD patients, 40 healthy controls, and 20 disease controls. All of the subjects underwent diffusion-tensor imaging (DTI) and resting-state functional magnetic resonance imaging (rs-fMRI). We calculated measures of structural and functional connectivities based on DTI and rs-fMRI, respectively, and investigated differences therein between the ESRD patients and the healthy controls. We assessed cognitive function in the ESRD patients using the Korean version of the Consortium to Establish a Registry for Alzheimer’s Disease neuropsychological battery.
Results:The ESRD patients exhibited decreased global structural and functional brain connectivities, as well as alterations of network hubs compared to the healthy controls and disease controls. About 70% of the ESRD patients had CI. Moreover, ESRD patients without CI exhibited decreased global connectivity and alterations of network hubs. Furthermore, there was a significant positive association between measures of brain connectivity and cognitive function.
Conclusions:We found that ESRD patients exhibited decreased structural and functional brain connectivities, and that there was a significant association between brain connectivity and cognitive function. These alterations in the brain network may contribute to the pathophysiological mechanism of CI in ESRD patients.
