Development of decision support system for antibody identification.
- Author:
Kyung Hwan CHOI
1
;
Kyou Sup HAN
;
Bok Yeon HAN
;
Jin Tae SUH
;
Suhng Gwon KIM
;
Han Ik CHO
Author Information
1. Office of Medical Informatics, Seoul National University College of Medicine.
- Publication Type:In Vitro ; Original Article
- Keywords:
Antibody Identification test;
Antigram;
Decision Support System;
Expert System;
Computer
- MeSH:
Adsorption;
Antibodies;
Antibody Specificity;
Blood Banks;
Expert Systems;
Humans
- From:Korean Journal of Blood Transfusion
1998;9(2):167-173
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Determination of antibody specificity using antigram spread sheet requires experience and knowledge on in vitro characteristics of red cell antibodies, time-consuming, and still subjective to human error. A computer-based antibody identification system was developed to overcome these disadvantages. METHODS: Decision support system program for antibody identification was designed using Visual Basic 5.0 for Dade Data-cyte Plus. This system integrates the reaction patterns of saline, 37degrees C albumin, antiglobulin, 4degrees C saline enzyme treated and user-defined phases and lists the antibodies according to the probability. 115 irregular antibodies previously confirmed by standard manual method reanalyzed with this program. RESULTS: In 111 of 115 cases (96.5%), this system produced the same results with the manual identification. In two cases, of not matched 4 cases the computer program suggested additional antibodies and in one case, the computer program detected previous human error. In the other case, antibody identification was possible only after further tests including selective adsorption of multiple antibodies. CONCLUSION: The decision support system was rapid and easy and showed good concordance rate when compared with manual antibody identificaion results. In addition, human error could be reduced. Decision support system for antibody identification could be used in small blood banks by less experienced staffs.
