A case of anti-LebH antibody concurrent Leb antigen suppression during pregnancy in a patient with idiopathic thrombocytopenic purpura.
- Author:
Seok Goo CHO
1
;
Jihyang LIM
;
Yonggoo KIM
;
Kyungja HAN
;
Chi Hwa HAN
;
An Hee LEE
;
Kyou Sup HAN
;
Chun Choo KIM
;
Kyung Shick LEE
Author Information
1. Department of Internal Medicine, Catholic University College of Medicine, Seoul, Korea.
- Publication Type:Case Report
- Keywords:
anti-LebH;
pregnancy;
Lewis
- MeSH:
Adult;
Anemia;
Cesarean Section;
Female;
Humans;
Immunoglobulins;
Phenotype;
Pregnancy*;
Purpura, Thrombocytopenic, Idiopathic*;
Thrombocytopenia
- From:Korean Journal of Blood Transfusion
1998;9(2):283-287
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
We report the first case of anti-LebH antibody concurrent Leb antigen supression during pregnency. A 32-year-old woman was diagnosed as idiopathic thrombocytopenic purpura at the 20th week of gestation. She was administrated intravenous immunoglobulin and transfused packed red cells due to thrombocytopenia and anemia. Before an elective cesarean section at 38th week of gestation, her red cells were typed B, Rh(D) positive and her serum had anti-A and her Lewis phenotype was Le(a-b-). The antibody screeening test was positive and anti-Leb which was identified in the antibody identification test. However, it revealed stronger reaction against O, Le(a-b+) red cells than B, Le(a-b+) red cells and we concluded that it was anti-LebH. About 1 year after delivery, the anti-LebH was detected as low titer (about 1:4) but Lewis phenotype was converted to original phenotype as Le(a-b+).
