The Influence of Family History on Stage and Survival of Gastric Cancer According to the <i<TGFB1 C-509T Polymorphism in Korea

Author: Hee Jin KIM ¹ ; Mingu KWON ; Nayoung KIM ; Jae Bong LEE ; Sungho WON
Author Information

1. Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea
Publication Type:Original Articles
From:Gut and Liver 2020;14(1):79-88
CountryRepublic of Korea
Language:English
Abstract: Background/Aims:The survival rate of gastric cancer (GC) is known to be higher in patients with a family history (FH) of GC. There is an association between a polymorphism in the transforming growth factor-β1 (
Methods:
Results:The proportion of stage I–II GCs was significantly higher in patients with a FH than in those without a FH of GC (83.8 vs 74.9%, p=0.005). The association between a FH of GC and stage I–II GC was not significant in subgroups divided based on the
Conclusions:Patient with a FH of GC had lower cancer stage (I–II) at diagnosis than those without a FH of GC, but there was no significant difference in overall survival between the patients with and without a FH of GC. A FH did not influence the tumor stage or overall survival in patients stratified by the presence of the