Effect of Oral Nifedipine on the Temporal Peripapillary.
- Author:
Joon Young HYON
1
;
Jae Jun LEE
;
Dong Myung KIM
Author Information
1. Department of Ophthalmology, Seoul National University College of Medicine #28 Yeongun-dong, Chongro-ku, Seoul, 110-744, Korea.
- Publication Type:Original Article
- Keywords:
Blood flow;
Calcium channel blocker;
Nifedipine;
Normal-tension glaucoma
- MeSH:
Administration, Oral;
Flowmeters;
Glaucoma;
Hemodynamics;
Humans;
Nifedipine*;
Optic Nerve;
Retina
- From:Journal of the Korean Ophthalmological Society
2000;41(11):2386-2390
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Compromise of the tissue circulation plays a significant role in the development of optic nerve damage in normal-tension glaucoma (NTG). To evaluate the effect of nifedipine on the blood flow of peripapillary retina, blood flow of 7 NTG patients were measured using Heidelberg Retina Flowmeter before and 1 hour after oral administration of nifedipine 5 mg.Before treatment, NTG eyes had significantly reduced blood flow than control eyes (245.99+/-132.91 vs.303.38 +/-121.07, p=0.036).After treatment, nifedipine increased blood flow (245.99 +/-132.91 vs.329.37 +/-189.17, p=0.005)and decreased intercapillary square (49.78 +/-17.30 micrometer vs.47.13 +/-15.13 micrometer , p=0.049)significantly in the NTG eyes, but did not affect blood flow in the control eyes (303.38 +/-121.07 vs.309 +/-85.53, p=0.756).These results show that glaucomatous optic nerve damage is accompanied with blood flow deficits and nifedipine improve ocular hemodynamics in normal-tension glaucoma.
