Liver-lung axes in alcohol-related liver disease

Author: Gavin E. ARTEEL ¹
Author Information

1. Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, Pittsburgh Liver Research Center, University of Pittsburgh, Pittsburgh, PA, USA
Publication Type:Special topic: Alcoholic liver diseases The 14th International Symposium on Alcoholic Liver and
From:Clinical and Molecular Hepatology 2020;26(4):670-676
CountryRepublic of Korea
Language:English
Abstract: Alcohol-related liver disease (ALD) and alcohol-related susceptibility to acute lung injury are the leading causes of morbidity and mortality due to chronic alcohol abuse. Most commonly, alcohol-induced injury to both organs are evaluated independently, although they share many parallel mechanisms of injury. Moreover, recent studies indicate that there is a potential liver lung axis that may contribute to organ pathology. This mini-review explores established and potential mechanisms of organ-organ crosstalk in ALD and alcohol-related lung injury.