Vitamin D Supplementation is Beneficial for Children with Autism Spectrum Disorder: A Meta-analysis
10.9758/cpn.2020.18.2.203
- Author:
Liyao SONG
1
;
Xiaomei LUO
;
Qing JIANG
;
Zhi CHEN
;
Lifang ZHOU
;
Dan WANG
;
Ai CHEN
Author Information
1. Department of Pediatrics, The Affiliated Hospital of Southwest Medical University, Luzhou
- Publication Type:Original Article
- From:Clinical Psychopharmacology and Neuroscience
2020;18(2):203-213
- CountryRepublic of Korea
- Language:0
-
Abstract:
Objective:We conducted a meta-analysis of randomized controlled trials to explore whether vitamin D supplementation is beneficial for symptom improvement in children with autism spectrum disorder.
Methods:We systematically searched the PubMed database, EMBASE, Cochrane Library, Web of Science, Sino-Med, Wanfang Data, and China National Knowledge Infrastructure mainly up to September 2019. Using a fixed effects model, we calculated the standard mean difference with 95% confidence interval. Furthermore, we analyzed baseline serum 25-hydroxyvitamin D levels and outcome scores including the Social Responsiveness Scale and Child Autism Rating Scale scores after vitamin D supplementation.
Results:There was no significant difference in baseline serum 25-hydroxyvitamin D levels among 203 children included from three studies in the meta-analysis. After vitamin D supplementation, the outcome scores in the experimental group were dramatically elevated compared with those in the control group (p = 0.03).
Conclusion:Vitamin D supplementation improves the typical symptoms of autism spectrum disorder, as indicated by reduced Social Responsiveness Scale and Child Autism Rating Scale scores; thus, it is beneficial for children with autism spectrum disorder.
