Immune Activation and Deficit in Neurotransmitters Synthesis in Treatment Resistant Depression: About a Case of Hashimoto Encephalopathy
10.9758/cpn.2020.18.3.463
- Author:
Pierre ELLUL
1
;
Matthieu GASNIER
;
Vincent TREBOSSEN
;
Raphael GAILLARD
Author Information
1. Sorbonne Université, Assistance Publique-Hôpitaux de Paris (AP-HP), Robert Debré Hospital, Department of Child and Adolescent Psychiatry, Paris, France
- Publication Type:Case Report
- From:Clinical Psychopharmacology and Neuroscience
2020;18(3):463-466
- CountryRepublic of Korea
- Language:English
-
Abstract:
We report a case of Hashimoto encephalopathy initially presented as a drug-resistant depression with predominant apathy and asthenia, successfully treated with cyclophosphamide. We suspected that the psychiatric symptoms were due to a deficit in neurotransmitter synthesis related to immune activation. We hypothesized that the immunomodulatory treatment helped to restore the neurotransmitter synthesis and thus decreased the patient’s depressive symptoms. In this case report we propose an innovative model in which immunity might disturbs neurotransmitters synthesis leading to depressive symptoms.
