Introduction of the Reliable Estimation of Atopic Dermatitis in ChildHood: Novel, Diagnostic Criteria for Childhood Atopic Dermatitis.
10.4168/aair.2016.8.3.230
- Author:
Seung Chul LEE
1
;
Jung Min BAE
;
Ho June LEE
;
Hyun Jung KIM
;
Byung Soo KIM
;
Kapsok LI
;
Jae We CHO
;
Chang Ook PARK
;
Sang Hyun CHO
;
Kwang Hoon LEE
;
Do Won KIM
;
Chun Wook PARK
;
Kyu Han KIM
Author Information
1. Department of Dermatology, Chonnam National University Medical School, Gwangju, Korea. schul@jnu.ac.kr
- Publication Type:Original Article
- Keywords:
Atopic dermatitis;
diagnostic criteria;
REACH;
questionnnaire
- MeSH:
Dermatitis;
Dermatitis, Atopic*;
Prevalence;
Sensitivity and Specificity
- From:Allergy, Asthma & Immunology Research
2016;8(3):230-238
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: Questionnaire-based diagnostic criteria for atopic dermatitis (AD) have been proposed to detect the major group of AD with flexural dermatitis. We aimed to develop novel, questionnaire-based diagnostic criteria for childhood AD, which can detect more comprehensive AD including non-flexural type. METHODS: The draft version of questionnaire to detect childhood AD was prepared to be used for preliminary hospital- (n=1,756) and community-based (n=1,320) surveys. From analysis, the Reliable Estimation of Atopic dermatitis of ChildHood (REACH) was derived and verified in derivation (n=1,129) and validation (n=1,191) sets by community-based surveys. RESULTS: The REACH consists of 11 questions including 2 major and 9 minor criteria. AD is diagnosed as the major group of 'eczema on the antecubital or popliteal fossa' to fulfill the 2 major criteria (2M), and the minor group of 'eczema on the non-antecubital or popliteal fossa' to fulfill the 1 major plus 4 or more minor criteria (1M+4m). In the validation set, the overall 1-year AD prevalence by the REACH was estimated as 12.3% (95% CI, 10.5%-14.2%), and the REACH showed a sensitivity of 75.2%, a specificity of 96.1%, and an error rate of 6.4%. The REACH demonstrated better diagnostic performance than the ISAAC in terms of the number of misclassification (10.0%). CONCLUSIONS: We propose the REACH as new full, questionnaire-based diagnostic criteria for childhood AD in epidemiological surveys. Further studies are warranted to validate the REACH in different populations or countries in the context of large-scale, epidemiological surveys.
