A Case of Pranlukast-Induced Anaphylactic Shock.
10.4168/aair.2016.8.3.276
- Author:
Sujeong KIM
1
;
Jong Myung LEE
Author Information
1. Department of Internal Medicine, Kyungpook National University School of Medicine, Daegu, Korea. jomlee@knu.ac.kr
- Publication Type:Case Report
- Keywords:
Pranlukast;
leukotriene antagonists;
anaphylaxis
- MeSH:
Aged;
Anaphylaxis*;
Angioedema;
Asthma;
Drug-Related Side Effects and Adverse Reactions;
Female;
Humans;
Hypersensitivity;
Leukotriene Antagonists;
Rhinitis;
Skin;
Unconsciousness;
Urticaria
- From:Allergy, Asthma & Immunology Research
2016;8(3):276-278
- CountryRepublic of Korea
- Language:English
-
Abstract:
Leukotriene receptor antagonists, which are generally considered safe with a few adverse drug reactions, are increasingly used in the treatment of various allergic diseases, including asthma and allergic rhinitis. Although a few anaphylactic reactions to montelukast have been reported worldwide, there is still a lack of reports about severe adverse drug reactions associated with pranlukast. Here, we report a case of severe hypersensitivity reaction associated with pranlukast. A 65-year-old woman developed anaphylactic shock that presented as generalized urticaria, angioedema, collapse, and loss of consciousness after receiving pranlukast. A positive response to oral challenge and skin prick testing with pranlukast was observed in the patient. In this case, it was demonstrated that pranlukast can induce anaphylaxis, possibly mediated by the IgE-dependent pathway.
