Angiotensin receptor-neprilysin inhibitor for the treatment of heart failure: a review of recent evidence
- Author:
Hong-Mi CHOI
1
;
Mi-Seung SHIN
Author Information
- Publication Type:1
- From:The Korean Journal of Internal Medicine 2020;35(3):498-513
- CountryRepublic of Korea
- Abstract: Heart failure (HF) is a growing health concern in aging societies worldwide. Sacubitril/valsartan is changing the real-world treatment in the whole spectrum of HF. The beginning was the PARADIGM-HF trial published in 2014, which demonstrated the beneficial effects of inhibiting natriuretic peptide breakdown in combination with hindering the renin-angiotensin system in HF patients with a reduced ejection fraction. Subsequent large-scale randomized trials have evaluated angiotensin receptor-neprilysin inhibitor in HF patients with acute decompensation or with preserved ejection fraction. The post hoc analyses are being conducted as well. This review summarizes the recent evidence of sacubitril/ valsartan regarding patient-centered outcomes, based on randomized controlled trials and their associated studies.
