Comparison of Gastroesophageal Reflux Disease Symptoms and Proton Pump Inhibitor Response Using Gastroesophageal Reflux Disease Impact Scale Questionnaire.
- Author:
So Young JO
1
;
Nayoung KIM
;
Ji Hwan LIM
;
Cheol Min SHIN
;
Young Soo PARK
;
Dong Ho LEE
;
Hyun Chae JUNG
Author Information
1. Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Gyeonggi-do, Korea. nayoungkim49@empas.com
- Publication Type:Original Article
- Keywords:
Functional heartburn;
Gastroesophageal reflux;
Proton pump inhibitors;
Quality of life;
Questionnaires
- MeSH:
Alcohol Drinking;
Body Mass Index;
Chest Pain;
Eating;
Endoscopy;
Esophagitis;
Gastroesophageal Reflux;
Hand;
Heartburn;
Hernia, Hiatal;
Hoarseness;
Humans;
Hydrogen-Ion Concentration;
Male;
Prospective Studies;
Proton Pump Inhibitors;
Proton Pumps;
Protons;
Quality of Life;
Surveys and Questionnaires;
Risk Factors;
Smoke;
Smoking
- From:Journal of Neurogastroenterology and Motility
2013;19(1):61-69
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND/AIMS: To compare gastroesophageal reflux disease (GERD) symptoms and response to proton pump inhibitor (PPI) in patients with erosive esophagitis (EE), non-erosive reflux disease (NERD) or functional heartburn (FH) using GERD impact scale (GIS) questionnaire. METHODS: Total 126 patients with GERD symptoms were diagnosed as EE (n = 62), NERD (n = 34) and FH (n = 30) by endoscopy, 24-hour esophageal pH testing and Bernstein test, prospectively. Analysis of risk factors and GIS questionnaire for GERD symptoms and quality of life were performed before and 8 weeks after PPI treatment. RESULTS: EE group had a higher proportion of men, frequent alcohol consumption, smoking, hiatal hernia, body mass index > or = 25 kg/m2 and triglyceride levels (> or = 150 mg/dL) than the other groups (all P < 0.05). On the other hand, both psychiatric treatment and psychopharmacotherapy were more frequent in patients with FH than in those with EE and NERD (both P < 0.05). Among GERD symptoms, chest pain was more frequent in FH group than in EE and NERD groups (P < 0.05). Eating problems and limitation of productive daily activities occurred frequently in FH group and NERD group, respectively. GIS after 8 week PPI treatment showed improvement in all of the GERD symptoms in EE (all P < 0.05) and in acid regurgitation, epigastric pain and hoarseness in NERD group (all P < 0.05). In terms of quality of life, PPI treatment improved sleep disturbance in EE (P = 0.031) and limitation of productive activity in the NERD group (P = 0.001). CONCLUSIONS: GIS questionnaire showed that different characteristics and symptoms improved after PPI therapy among patients with EE, NERD and FH, demonstrating the usefulness of the GIS questionnaire.
