Cardiac Manifestations of Coronavirus Disease 2019 (COVID-19): a Multicenter Cohort Study
10.3346/jkms.2020.35.e366
- Author:
Minkwan KIM
1
;
Jong-Ho NAM
;
Jang-Won SON
;
Sun Oh KIM
;
Nak-Hoon SON
;
Chul-Min AHN
;
Chi Young SHIM
;
Geu-Ru HONG
;
In-Cheol KIM
;
Jinwoo CHOI
;
Seung-Mo KANG
;
Yeoung Ho CHOI
;
Hae Kyoung YOON
;
Jae-Sun UHM
;
In Hyun JUNG
Author Information
1. Division of Cardiology, Department of Internal Medicine, Yongin Severance Hospital, Yonsei University College of Medicine, Yongin, Korea
- Publication Type:Original Article
- From:Journal of Korean Medical Science
2020;35(40):e366-
- CountryRepublic of Korea
- Language:0
-
Abstract:
Background:This study aimed to investigate the cardiac manifestations of coronavirus disease 2019 (COVID-19).
Methods:From February to March 2020, we prospectively and retrospectively enrolled consecutive patients diagnosed with COVID-19. Patient's data such as the demographic characteristics, symptoms, vital signs, laboratory and radiologic findings, electrocardiographic, and echocardiographic data, including the global longitudinal strain (GLS) of both ventricles, were obtained.
Results:Forty patients (median age, 58 years; 50% men) were enrolled in the initial analysis. Patients were classified into severe and nonsevere groups based on the current guidelines. The 13 patients in the severe group were significantly older, had a greater prevalence of bilateral pneumonia and leukocytosis, and higher aspartate transaminase levels than patients in the nonsevere group. Patients in the severe group had a slightly lower left ventricular ejection fraction (LVEF) than those in the nonsevere group (median [interquartile range], 61.0% [58.5%, 62.3%] vs. 66.7% [60.6%, 69.8%], P = 0.015). In a subgroup of 34 patients in whom GLS could be analyzed, patients in the severe group had a significantly impaired left ventricular GLS (LVGLS) than those in the nonsevere group (−18.1% [−18.8%, −17.1%] vs. −21.7% [−22.9%, −19.9%], P = 0.001). There were no significant differences in total wall (RVGLS total , −19.3% [−23.9%, −18.4%] vs. −24.3% [−26.0%, −22.6%], P = 0.060) and free wall (RVGLS fw , −22.7% [−27.2%, −18.6%] vs. −28.8% [−30.4%, −24.1%], P = 0.066) right ventricle GLS (RVGLS).
Conclusion:Patients with severe COVID-19 had lower LVEF and LVGLS. RVGLS was not different between patients with severe and nonsevere COVID-19.
