A Case of Consumptive Hypothyroidism in a 1-Month-Old Boy with Diffuse Infantile Hepatic Hemangiomas
10.3346/jkms.2020.35.e180
- Author:
Young Ho KIM
1
;
Young Ah LEE
;
Choong Ho SHIN
;
Kyung Taek HONG
;
Gi Beom KIM
;
Jae Sung KO
;
Yun Jeong LEE
Author Information
1. Department of Pediatrics, Seoul National University Children's Hospital, Seoul, Korea
- Publication Type:Case Report
- From:Journal of Korean Medical Science
2020;35(22):e180-
- CountryRepublic of Korea
- Language:English
-
Abstract:
Consumptive hypothyroidism is a rare paraneoplastic syndrome characterized by excessive inactivation of the thyroid hormones due to increased type 3 iodothyronine deiodinase activity of tumors. We report the case of severe consumptive hypothyroidism in a 1-month-old boy with infantile hepatic hemangiomas who presented with cardiac failure and cholestasis. Diffuse infiltration of hepatic hemangiomas was detected on abdominal imaging studies, and thyroid function screening test revealed severe hypothyroidism, which necessitated the administration of higher-than-usual doses of levothyroxine for the normalization of thyroid function. The patient was successfully treated with propranolol, prednisolone, and levothyroxine, and he showed normal thyroid function at 3 months of age and normal neurodevelopment at 9 months of age. This case highlights the importance of early recognition and prompt management of consumptive hypothyroidism in patients with infantile hepatic hemangiomas.
