Acute Kidney Injury and Kidney Damage in COVID-19 Patients
10.3346/jkms.2020.35.e257
- Author:
Ki Ryang NA
1
;
Hae Ri KIM
;
Youngrok HAM
;
Dae Eun CHOI
;
Kang Wook LEE
;
Jae Young MOON
;
Yeon-Sook KIM
;
Shinhye CHEON
;
Kyung Mok SOHN
;
Jungok KIM
;
Sungmin KIM
;
Hyeongseok JEONG
;
Jae Wan JEON
Author Information
1. Department of Internal Medicine, Chungnam National University School of Medicine, Daejeon, Korea
- Publication Type:Original Article
- From:Journal of Korean Medical Science
2020;35(28):e257-
- CountryRepublic of Korea
- Language:0
-
Abstract:
Background:Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. This disease, which is quickly spreading worldwide, has high potential for infection and causes rapid progression of lung lesions, resulting in a high mortality rate. This study aimed to investigate the effects of SARS-CoV-2 infection on renal function in patients with COVID-19.
Methods:From February 21 to April 24, 2020, 66 patients diagnosed with COVID-19 at Chungnam National University Hospital were analyzed; all patients underwent routine urinalysis and were tested for serum creatinine, urine protein to creatinine ratio (PCR), and urine albumin to creatinine ratio (ACR).
Results:Acute kidney injury (AKI) occurred in 3 (4.5%) of the 66 patients, and 1 patient with AKI stage 3 underwent hemodialysis. Upon follow-up, all 3 patients recovered normal renal function. Compared with patients with mild COVID-19, AKI (n = 3) occurred in patients with severe COVID-19, of whom both urine PCR and ACR were markedly increased.
Conclusion:The incidence of AKI was not high in COVID-19 patients. The lower mortality rate in SARS-CoV-2 infection compared with previous Middle East respiratory syndrome and SARS-CoV infections is thought to be associated with a low incidence of dysfunction in organs other than the lungs.
