Prevalence and Incidence of Neuromyelitis Optica Spectrum Disorderin Korea: Population Based Study
10.3346/jkms.2020.35.e115
- Author:
Hye Lim LEE
1
;
Jae Young KIM
;
Jin Myoung SEOK
;
Yoon-Ho HONG
;
Nam Gu LIM
;
Ha Young SHIN
;
Byung-Jo KIM
;
Soon-Young HWANG
;
Ju-Hong MIN
;
Byoung Joon KIM
Author Information
1. Department of Neurology, Korea University College of Medicine, Seoul, Korea
- Publication Type:Original Article
- From:Journal of Korean Medical Science
2020;35(17):e115-
- CountryRepublic of Korea
- Language:English
-
Abstract:
Background:Although neuromyelitis optica spectrum disorder (NMOSD) is known to be a rare disease, its prevalence and incidence have not yet been studied in Korea. We performed a population-based study to examine the prevalence and incidence of NMOSD in Korea using data from the Korean National Health Insurance (NHI) claims database.
Methods:Data from 2013 to 2017 were obtained, with a washout period set as 2013 and 2014. The prevalence and incidence of NMOSD in 2016 and 2017 were calculated using population census data. Subjects were divided into 5 groups at 15-year intervals, depending on the age at which the diagnostic code was entered. The relative risk (RR) for each age group was compared with the oldest (≥ 60 years) age group.
Results:The overall prevalence was estimated to be 3.36 and 3.56 per 100,000 individuals, with an incidence of 0.41 and 0.65 per 100,000 individuals-year in 2016 and 2017, respectively. The mean age was 43.08 (standard deviation, 14.56) years, and the ratio of male to females was 1:4.7. The incidence was higher in female individuals aged between 30 and 59 years (RR, 2.8–3.05; P < 0.05).
Conclusion:Nationwide prevalence of NMOSD in Korea was 3.36 and 3.56/100,000 and its incidence was 0.41 and 0.65/100,000-year in 2016 and 2017 respectively.
