Possible Role of Lysine Demethylase 2A in the Pathophysiology of Psoriasis
- Author:
Dong Ha KIM
1
;
Mi-Ra CHOI
;
Jae Kyung LEE
;
Dong-Kyun HONG
;
Kyung Eun JUNG
;
Chong Won CHOI
;
Young LEE
;
Chang-Deok KIM
;
Young-Joon SEO
;
Jeung-Hoon LEE
Author Information
- Publication Type:ORIGINAL ARTICLE
- From:Annals of Dermatology 2020;32(6):481-486
- CountryRepublic of Korea
- Language:English
-
Abstract:
Background:Psoriasis is a common chronic inflammatory skin disease. The development of psoriasis is dependent on many intercellular events such as innate immunity and T cell-mediated inflammation. Furthermore, genetic factors are strongly implicated in the pathophysiology of psoriasis. Although a variety of susceptible genes are identified, it is likely that many important genes remain undisclosed.
Objective:The aim of this study is to investigate the possible role of lysine demethylase 2A (KDM2A) in the pathophysiology of psoriasis.
Methods:We examined the expression of KDM2A using a well established imiquimod-induced psoriasiform dermatitis model.
Results:Immunohistochemistry analysis showed that expression of KDM2A was increased in imiquimod-induced psoriasiform dermatitis. Consistent with this result, KDM2A level was markedly increased in the epidermis of psoriatic patient. When keratinocytes were stimulated with TLR3 agonist poly(I:C), KDM2A was increased at both the mRNA and protein levels. Poly(I:C) increased the expression of psoriasis-related cytokines including tumor necrosis factor-α, interleukin-8, and CCL20, and KDM2A inhibitor daminozide enhanced the poly(I:C)-induced cytokine expression. Finally, topical co-application of imiquimod and daminozide exacerbated the imiquimod-induced psoriasiform dermatitis.
Conclusion:Together, these results suggest that KDM2A is increased to negatively regulate the inflammatory reaction of epidermal keratinocytes in psoriasis.
