Role of B cell activating factor in the development of periodontitis
10.12016/j.issn.2096⁃1456.2020.12.008
- Author:
ZHANG Zheng
1
;
WANG Zuomin
2
Author Information
1. 1.Department of Periodontology, Tianjin Stomatological Hospital, Tianjin Key Laboratory of Oral Function Reconstruction, Nankai University 2.Department of Stomatology, Beijing Chao-Yang Hospital, Capital Medical University
2. Department of Stomatology, Beijing Chao-Yang Hospital, Capital Medical University
- Publication Type:Review
- Keywords:
periodontitis;
B cell;
B cell activating factor;
immune response;
saliva;
gingival crevicular fluid;
peripheral blood;
CD4+;
regulatory T cell;
M2 macrophage
- From:
Journal of Prevention and Treatment for Stomatological Diseases
2020;28(12):796-800
- CountryChina
- Language:Chinese
-
Abstract:
B cell activating factor (BAFF) is the key regulator of B cells and is considered as a potential therapeutic target for immune inflammatory diseases. Periodontitis can promote local and systemic BAFF factor expression, whereas BAFF aggravates B cell immune responses and tissue destruction in periodontitis. In addition, BAFF also stimulates CD4+T cell response and inhibits regulatory T cell and M2 macrophage responses, thus changing the pathogenesis of a variety of immune inflammatory diseases. However, whether the biological effect mentioned above is an important mechanism by which BAFF aggravates periodontitis still lacks direct evidence and should be confirmed in future research. To provide a theoretical basis for the study of the pathogenic mechanism of BAFF, the expression and role of BAFF in periodontitis is reviewed in this article.
- Full text:B细胞激活因子在牙周炎发生发展中的作用.pdf
