Rhabdomyolysis and localized myositis associated with amitiptyline overdose.
- Author:
Hyun Kyu CHANG
1
;
Nam Hyeon KIM
;
Young Joon CHOI
;
Gil Hyun KANG
;
Kyoung Sook WON
Author Information
1. Department of Internal Medicine, Asan-Foundation Kangnung Hospital, Kangnung, Korea.
- Publication Type:Case Report
- Keywords:
Amitriptyline overdose;
Rhabdomyolysis;
Localized myositis
- MeSH:
Adult;
Amitriptyline;
Arrhythmias, Cardiac;
Delirium;
Female;
Humans;
Muscular Diseases;
Myositis*;
Respiratory Distress Syndrome, Adult;
Rhabdomyolysis*;
Seizures;
Thigh
- From:Korean Journal of Medicine
1999;57(3):380-384
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Widespread use of amitriptyline in clinical practice has led to extensive knowledge of its therapeutic and toxic effects. In cases of amitriptyline overdose, delirium, arrhythmia, convulsion, and adult respiratory distress syndrome have been reported, but amitriptyline-associated rhabdomyolysis has been rarely reported in the literature. Several drugs are associated with myositis or myopathy, but amitriptyline-related myositis has not been reported. We describe a 40-year-old woman with rhabdomyolysis and localized myositis in left proximal thigh after she had taken 625mg of amitriptyline.
