Displacement of Surgical Clips in Patients with Human AcellularDermal Matrix in the Excision Cavity during Whole Breast IrradiationFollowing Breast-Conserving Surgery
- Author:
Wonguen JUNG
1
;
Kyubo KIM
;
Nam Sun PAIK
Author Information
- Publication Type:Original Article
- From:Cancer Research and Treatment 2020;52(2):388-395
- CountryRepublic of Korea
- Language:English
-
Abstract:
Purpose:The purpose of this study was to investigate the displacement of surgical clips in the excisioncavity during whole breast irradiation following breast-conserving surgery (BCS) with or withoutacellular dermal matrix (ADM) insertion, and to analyze clinicopathologic factors associatedwith the displacement of surgical clips.
Materials and Methods:From 2016 to 2017, 100 consecutive breast cancer patients who underwent BCS with theplacement of surgical clips (superior, inferior, medial, lateral, and deep sides) in the tumorbed were included in this study. All patients took first planning computed tomography (CT)scan (CT 1) before whole breast irradiation and second CT scan (CT 2) before boost irradiation.Between two sets of planning CT, the displacement of surgical clips was calculatedfrom the !X (lateral–medial), !Y (anterior–posterior), !Z (superior–inferior), and threedimensional(3D) directions. Patients were divided into two groups according to the breastvolume replacement with ADM: group A with ADM and group B without ADM.
Results:The means and 1 standard deviations of 3D displacement for superior, inferior, medial, lateraland deep clips were 5.2±2.9, 5.2±3.2, 5.6±4.5, 5.6±4.3, and 4.9±4.9 mm in entirecohort (n=100); 5.6±2.6, 6.0±3.5, 6.7±5.8, 6.7±5.7, and 6.1±7.4 mm in group A (n=38);4.9±3.1, 4.8±3.0, 5.0±3.5, 5.0±2.9, and 4.3±2.8 mm in group B (n=62), respectively. The3D displacements of group A were longer than those of group B, but only significant differencewas observed in lateral clip (p=0.047).
Conclusion:This study demonstrated displacement of surgical clips during whole breast irradiation inpatients with ADM insertion. For patients who had breast volume replacement using ADM,adaptive boost planning should be considered.
