Outcomes of Pregnancy after Breast Cancer in Korean Women:A Large Cohort Study
- Author:
Moo Hyun LEE
1
;
Young Ae KIM
;
Jin Hyuk HONG
;
So-Youn JUNG
;
Sunmi LEE
;
Sun-Young KONG
;
Boyoung PARK
;
Eun Sook LEE
Author Information
- Publication Type:Original Article
- From:Cancer Research and Treatment 2020;52(2):426-437
- CountryRepublic of Korea
- Language:0
-
Abstract:
Purpose:The purpose of this study was to determine the rate and outcomes of pregnancies subsequentto breast cancer in Korea, and the effect of such pregnancies on the prognosis ofwomen who survived breast cancer and subsequently conceived.
Materials and Methods:We followed a total of 31,761 Korean women 45 years of age or younger who were treatedfor primary breast cancer from 2002 to 2010. We also included follow-up surveys that wereconducted through December 2011. We identified recurrence and mortality from breastcancer using data linked to the Korea National Health Insurance database. We used propensityscore matching of the study cohort to analyze the risks of recurrence and mortality frombreast cancer depending on pregnancy.
Results:Within our sample, 992 women (3.1%) became pregnant after receiving treatment for breastcancer. Of those, 622 (67.5%) successfully delivered; the remaining 370 (32.5%) failed todeliver. After propensity score matching, we found that the women who became pregnantafter breast cancer did not have a different risk of recurrence (hazard ratio [HR], 0.503;95% confidence interval [CI], 0.434 to 0.584) and death (HR, 0.520; 95% CI, 0.397 to0.681), compared with those who did not conceive after breast cancer treatment.
Conclusion:Our study is the first to report outcomes for Korean women who survived breast cancer andsubsequently conceived. Women who survived breast cancer and subsequently becamepregnant did not show a poorer survival outcome, compared with those who did not becomepregnant.
