Effects of Long Term Administration of Vitamin A on Lipids of Liver Tissue and Serum in Rat.
- Author:
In Joo KIM
;
Jae Kyung SOHN
;
Sang Lip CHUNG
;
Jung Chul KIM
;
Tae Ho CHUNG
- Publication Type:Original Article
- Keywords:
Vitamin A levels;
Serum;
Liver tissue;
Rat
- MeSH:
Animals;
Cholesterol;
Cholesterol Esters;
Liver*;
Rats*;
Triglycerides;
Vitamin A*;
Vitamins*
- From:Korean Journal of Dermatology
1986;24(6):743-750
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
This study was carried out to determine the effect of long term administration of vitamin A on the changes of lipids in liver tissue and serum in rat. The animals were fed with control diet(200 ug/day) and high vitimin A diet(2, 000 ug/day) for 24 weeks. Vitamin A contents of liver in high vitamin A fed rats were increased linearly accordance with duration of the vitamin A administration, but levels of serum vitamin A showed unremarkable changes during the experimental period. Contents of cholesterol and triglycerides of vitarnin A fed rats were significantly higher than those of controls. Levels of HDL-triglycerides in v:itamin A fed rats were significantly higher than those of control rats during experimental period, while levels of HDL-cholesterol and HDL-phospholipids showed unremarkable changes during experimental period. Levels of individual cholesteryl esters showed undremarkable changes during experimental period in both animal groups.
