Effect of H2 - Receptor Antagonists on UVB - Suppressed Contact Hypersensitivity.
- Author:
Dae Sung LEE
;
Baik Kee CHO
;
Won HOUH
- Publication Type:Original Article
- Keywords:
UVB;
Cimetidine;
Ranitidine
- MeSH:
Cimetidine;
Dermatitis, Contact*;
Dinitrochlorobenzene;
Histamine;
Ranitidine
- From:Korean Journal of Dermatology
1986;24(6):787-792
- CountryRepublic of Korea
- Language:English
-
Abstract:
The effects of histamine type 2(H2) receptor antagonists, cimetidine and ranitidine, on the induction of contact hypersensitivity and UVB induced suppression of contact hypersensitivity were studied. Our experiment showed that treatment with cimetidine or ranitidine slightly enhanced contact hypersensitivity to DNCB, but the suppression of contact hypersensitivity elicited by UVB were moderatly reversed by ranitidine. These facts suggest that H2-receptor antagonist may be responsible for th blocking histamine induced suppressor factor by acting upon UV-induced suppressor T cell.
