The Therapeutic Potential of Conditioned Medium from Human Breast Milk Stem Cells in Treating Spinal Cord Injury
- Author:
Maryam BORHANI-HAGHIGHI
1
;
Shadan NAVID
;
Yousef MOHAMADI
Author Information
- Publication Type:Basic Study
- From:Asian Spine Journal 2020;14(2):131-138
- CountryRepublic of Korea
- Language:0
-
Abstract:
Methods:Human BMSCs were isolated and characterized, and CM was subsequently collected. Animals received an intrathecal administration of BMSC-CM after SCI. The activity of caspase-3 was measured to assess apoptosis, and levels of tumor necrosis factor-α and interleukin-1β were measured to assess inflammation. Also, sensory and locomotor performances were assessed after SCI and BMSC-CM administration.
Results:Administration of CM from BMSC reduced apoptosis and inflammation at the site of injury in a rat model of SCI (p<0.05). Motor, sensory, locomotor, and sensorimotor performances were significantly improved in rats that received BMSC-CM after SCI.
Conclusions:Intrathecal administration of BMSC-CM improved recovery in a rat model of SCI.
