Bone Marrow Findings, and TNF-alpha, IL-18 Expression in Bone Marrow of Adult Onset Still's Disease Patients.
10.4078/jkra.2009.16.2.87
- Author:
Kyong Hee JUNG
1
;
Hye Yong KIM
;
Chang Nam SON
;
Joo Hyung KIM
;
Won Jun KIM
;
Kyeong A LEE
;
Ho Hyun PARK
;
Woong Soo LEE
;
Dae Hyun YOO
Author Information
1. Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Adult onset Still's disease;
Tumor necrosis factor-alpha;
Interleukin-18;
Bone marrow
- MeSH:
Adult;
Arthritis, Juvenile Rheumatoid;
Asian Continental Ancestry Group;
Bone Marrow;
Bone Marrow Cells;
Bone Marrow Examination;
Cytokines;
Humans;
Immunohistochemistry;
Interleukin-18;
Platelet Count;
Retrospective Studies;
Still's Disease, Adult-Onset;
Tumor Necrosis Factor-alpha
- From:The Journal of the Korean Rheumatism Association
2009;16(2):87-94
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: Inflammatory cytokines may play important roles in the pathogenesis of adult onset Still's disease. The enhanced expression of IL-18 was reported in the bone marrow of a Japanese systemic onset juvenile rheumatoid arthritis patient but not in the other organs. To date, there are very few studies relating the bone marrow and AOSD. This study examined the bone marrow findings as well as TNF-alpha and IL-18 expression in the bone marrow of AOSD patients. METHODS: A retrospective study was performed on 15 AOSD patients who had undergone a bone marrow examination at a university hospital. The clinical and laboratory findings, as well as the bone marrow findings, were analyzed. Immunohistochemistry of IL-18 and TNF-alpha in bone marrow was performed. RESULTS: The bone marrow cellularity and myeloid/erythroid cell ratio showed no correlation with the clinical and laboratory findings. TNF-alpha was expressed at 0.8~9.8% and IL-18 was expressed at 0.4~9.8% of bone marrow cells. Cytokine expression was not associated with the clinical patterns of AOSD. The platelet count correlated with the bone marrow TNF-alpha expression but TNF-alpha did not correlate with IL-18 expression. CONCLUSION: TNF-alpha and IL-18 expression in bone marrow were observed in some AOSD patients but there was no correlation with the other clinical and laboratory findings except for the platelet count.
