Characteristics of minute T1 colorectal cancer in relevance to pathology and treatment
10.4174/astr.2020.98.4.199
- Author:
Sin Hye PARK
1
;
Seon Ok OH
;
Sung Sil PARK
;
Seung Jae ROH
;
Kyung Su HAN
;
Bun KIM
;
Chang Won HONG
;
Byung Chang KIM
;
Dae Kyung SOHN
;
Hee Jin CHANG
;
Sung Chan PARK
;
Jae Hwan OH
Author Information
1. Center for Colorectal Cancer, Research Institute and Hospital, National Cancer Center, Goyang, Korea
- Publication Type:ORIGINAL ARTICLE
- From:Annals of Surgical Treatment and Research
2020;98(4):199-205
- CountryRepublic of Korea
-
Abstract:
Purpose:Minute T1 colorectal cancer (CRC) lesions (≤5 mm) are rare; however, little is known about their characteristics and aggressiveness. In this study, we evaluated the characteristics of minute T1 CRC in relevance to pathology and treatment.
Methods:This retrospective study included 849 patients with T1 CRC endoscopically or surgically treated between January 2001 and December 2016. The patients were stratified into 4 groups according to tumor size; minute group (≤5 mm), small group (6–10 mm), medium group (11–20 mm), and large group (≥21 mm). Clinicopathological variables were evaluated with respect to tumor size.
Results:The incidence of the minute T1 CRC was 2.4% (20 of 849). Minute T1 CRC was significantly associated with flat type (minute, 25%; small, 12.6%; medium, 8.8%; large, 12.6%; P = 0.016), right-sided cancer (30%, 15.4%, 15.4%, 15.1%, P = 0.002) and the absence of background adenoma (BGA) (50%, 40.7%, 32.8%, 18.1%, P < 0.001). In patients who underwent surgery, lymph node metastasis (LNM) was significantly higher in the minute group (36.4%, 15.9%, 15.7%, 9.2%, P = 0.029).
Conclusion:Minute T1 CRC is significantly associated with flat type, right-sided cancers, as well as with the absence of BGA and LNM. These results suggested the minute T1 CRC lesions are often aggressive and are likely to be missed during colonoscopy.
