Comparison of proinsulin to C-peptide ratio in children with and without type 1 diabetes and its relation to age
10.6065/apem.2020.25.1.38
- Author:
Benjamin R. ELLISON
1
;
Jeffrey H. BURTON
;
Daniel S. HSIA
Author Information
1. Baylor University, Waco, TX, USA
- Publication Type:Original Article
- From:Annals of Pediatric Endocrinology & Metabolism
2020;25(1):38-41
- CountryRepublic of Korea
-
Abstract:
Purpose:This study aimed to compare the proinsulin to C-peptide (PI:C) ratio in those with recent-onset type 1 diabetes versus those with no diabetes and to explore the effect of age on PI:C ratio.
Methods:Nineteen participants (n=9 with type 1 diabetes and n=10 with no diabetes) between 10 and 19 years of age were enrolled in a single-visit cross-sectional study and underwent blood collection after 10 hours fasting to measure proinsulin and C-peptide levels as well as other glycemic parameters.
Results:The median PI:C ratio was significantly different between type 1 diabetes and nondiabetes groups (6.24% vs. 1.46%, P<0.01). A significant negative correlation was seen between PI:C ratio and patient age after adjustment for duration of diabetes (r2=0.61, P=0.02) in the type 1 diabetes group.
Conclusion:Even in this narrow age window, a higher degree of β-cell dysfunction indicated by a higher PI:C ratio was seen in younger children.
