Effects of BCG, lymphotoxin and bee venom on insulitis and development of IDDM in non-obese diabetic mice.
10.3346/jkms.1999.14.6.648
- Author:
Jong Yeon KIM
1
;
Sung Hyun CHO
;
Yong Woon KIM
;
Eung Chan JANG
;
So Young PARK
;
Eun Jung KIM
;
Suck Kang LEE
Author Information
1. Department of Physiology, Yeungnam University College of Medicine, Taegu, Korea.
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Diabetes mellitus;
Insulin-dependent;
Autoimmunity;
Cytokiness
- MeSH:
Adjuvants, Immunologic/pharmacology*;
Age Factors;
Animal;
Bee Venoms/pharmacology*;
Cholesterol/blood;
Diabetes Mellitus/prevention & control*;
Diabetes Mellitus/immunology;
Diabetes Mellitus, Insulin-Dependent/prevention & control*;
Diabetes Mellitus, Insulin-Dependent/immunology;
Disease Models, Animal;
Female;
Islets of Langerhans/pathology*;
Islets of Langerhans/drug effects;
Lymphotoxin/pharmacology*;
Mice;
Mice, Inbred NOD;
Mycobacterium bovis/immunology*;
Triglycerides/blood
- From:Journal of Korean Medical Science
1999;14(6):648-652
- CountryRepublic of Korea
- Language:English
-
Abstract:
To investigate whether BCG, lymphtoxin (LT) or bee venom (BV) can prevent insulitis and development of diabetes in non-obese diabetic (NOD) mice, we measured the degree of insulitis and incidence of diabetes in 24 ICR and 96 female NOD mice. NOD mice were randomly assigned to control, BCG-, LT-, and BV-treated groups. The BCG was given once at 6 weeks of age, and LT was given in 3 weekly doses from the age of 4 to 10 weeks. The BV was injected in 2 weekly doses from the age of 4 to 10 weeks. Diabetes started in control group at 18 weeks of age, in BCG group at 24 weeks of age, and in LT- or BV-treated group at 23 weeks of age. Cumulative incidences of diabetes at 25 weeks of age in control, BCG-, LT-, and BV-treated NOD mice are 58, 17, 25, and 21%, respectively. Incidence and severity of insulitis were reduced by BCG, LT and BV treatment. In conclusion, these results suggest that BCG, LT or BV treatment in NOD mice at early age inhibit insulitis, onset and cumulative incidence of diabetes.
