Long-term Oncologic Outcome of Postoperative Complications After Colorectal Cancer Surgery
- Author:
Chang Kyu OH
1
;
Jung Wook HUH
;
You Jin LEE
;
Moon Suk CHOI
;
Dae Hee PYO
;
Sung Chul LEE
;
Seong Mun PARK
;
Jung Kyong SHIN
;
Yoon Ah PARK
;
Yong Beom CHO
;
Seong Hyeon YUN
;
Hee Cheol KIM
;
Woo Yong LEE
Author Information
- Publication Type:Original Article
- From:Annals of Coloproctology 2020;36(4):273-280
- CountryRepublic of Korea
-
Abstract:
Purpose:The impact of postoperative complications on long-term oncologic outcome after radical colorectal cancer surgery is controversial. The aim of this study was to examine the risk factors and oncologic outcomes of surgery-related postoperative complication groups.
Methods:From January 2010 to December 2010, 310 patients experienced surgery-related postoperative complications after radical colorectal cancer surgery. These stage I–III patients were classified into 2 subgroups, minor (grades I, II) and major (grades III, IV) complication groups, according to extended Clavien-Dindo classification system criteria. Clinicopathologic differences between the 2 groups were analyzed to identify risk factors for major complications. The diseasefree survival rates of surgery-related postoperative complication groups were also compared.
Results:Minor and major complication groups were stratified with 194 patients (62.6%) and 116 patients (37.4%), respectively. The risk factors influencing the major complication group were pathologic N category and operative method. The prognostic factors associated with disease-free survival were preoperative perforation, perineural invasion, tumor budding, and receiving neoadjuvant therapy. With a median follow-up period of 72.2 months, the 5-year disease-free survival rates were 84.4% in the minor group and 78.5% in the major group, but there was no statistical significance between the minor and major groups (P = 0.392).
Conclusion:Advanced cancer and open surgery were identified as risk factors for increased surgery-related major complications after radical colorectal cancer surgery. However, severity of postoperative complications did not affect disease-free survival from colorectal cancer.
