Behcet's disease associated with myelodysplastic syndrome: a case report.
10.3346/jkms.1999.14.6.685
- Author:
Eun Jee OH
1
;
Jeong Sook YOON
;
Yeon Joon PARK
;
Cheol Soo CHO
;
Byung Kee KIM
Author Information
1. Department of Clinical Pathology, Catholic University of Korea, Seoul, Korea. ejoh@cmc.cuk.ac.kr
- Publication Type:Case Report
- Keywords:
Myelodysplastic syndromes;
Behcet's syndrome;
Translocation (genetics);
Chromosomes, human, pair 8
- MeSH:
Anemia/genetics;
Behcet's Syndrome/genetics*;
Behcet's Syndrome/diagnosis;
Bone Marrow Cells/ultrastructure;
Bone Marrow Cells/pathology;
Case Report;
Chromosome Aberrations;
Female;
Histocytochemistry;
Human;
Korea;
Middle Age;
Myelodysplastic Syndromes/genetics*
- From:Journal of Korean Medical Science
1999;14(6):685-687
- CountryRepublic of Korea
- Language:English
-
Abstract:
A rare case of Behcet's disease associated with myelodysplastic syndrome (MDS) is described. A 50-year-old Korean female suffering recurrent oral ulcer, genital ulcer, fatigue, arthralgia in both knees and fever was diagnosed as Behcet's disease. The findings of bone marrow aspirates were consistent with refractory anemia, a subtype of myelodysplastic syndrome. Chromosomal analysis of bone marrow cells revealed 46,XX,-8,-20,+der(8)t(8;20)(p23;p10),+der(8) t(8;20)(p23;q10)[30]. The chromosomal changes found in this patient were different from those of previous reports, which mostly revealed trisomy 8. If anemia, low reticulocyte count and dyspoietic cells are sustained in Behcet's disease, physicians should be alert to the possibility of MDS with aberration in chromosome 8 and perform a bone marrow study for the proper diagnosis and treatment of the disease. We presented a case of Behcet's disease associated with MDS, which is the first Korean case.
