Comparison of palonosetron and ondansetron to prevent postoperative nausea and vomiting in women using intravenous patient-controlled analgesia
10.17085/apm.2020.15.1.28
- Author:
Jae Hwa YOO
1
;
In Suk JEON
;
Ji Won CHUNG
;
Jae Hoon RYOO
;
Gyu Wan YOU
;
Soon Im KIM
Author Information
1. Department of Anesthesiology and Pain Medicine, 1Soonchunhyang University Seoul Hospital, Seoul, Korea
- Publication Type:Clinical Research
- From:Anesthesia and Pain Medicine
2020;15(1):28-34
- CountryRepublic of Korea
-
Abstract:
Background:We compared the effects of palonosetron with ondansetron for preventing postoperative nausea and vomiting (PONV) during the first 24 h after surgery in women receiving intravenous patient-controlled analgesia (IV-PCA) with fentanyl for pain control.
Methods:In this prospective, randomized, double-blinded study, 204 healthy patients who were undergoing elective surgery with general anesthesia were enrolled. In the palonosetron group (n = 102), 0.075 mg bolus was given intravenously (i.v.) 30 min before the end of surgery and 8 ml saline was added to the IV-PCA. In the ondansetron group (n = 102), 8 mg bolus i.v. was given 30 min before the end of surgery and 16 mg of ondansetron was added to the IV-PCA. The incidence of PONV, severity of nausea, and use of rescue anti-emetics were evaluated 6 and 24 h after the operation.
Results:The incidences of nausea (55.6%) and vomiting (14.1%) in the palonosetron group did not differ from those (58.3 and 19.8%) in the ondansetron group during the first 24 h after surgery (P > 0.05). No significant differences were observed in the severity of nausea and use of rescue anti-emetics between the two groups (P > 0.05).
Conclusions:The effects of palonosetron in preventing PONV were not different from those of ondansetron during the first 24 h postoperatively in women receiving IV-PCA with fentanyl.
