A Case of Captopril-induced Pemphigus Foliaceus.
10.5021/ad.1990.2.1.63
- Author:
Ho Sun JANG
;
Doo Chan MOON
;
Kyung Sool KWON
;
Tae Ahn CHUNG
- Publication Type:Case Report
- Keywords:
Captopril;
Pemphigus foliaceus
- MeSH:
Aged;
Captopril;
Epidermis;
Extremities;
Heart Failure;
Humans;
Immunoglobulin G;
Korea;
Male;
Mucous Membrane;
Pemphigus*;
Skin
- From:Annals of Dermatology
1990;2(1):63-67
- CountryRepublic of Korea
- Language:English
-
Abstract:
A 65-year-old male received captoPnl therapy (25mg three times a day, for the treatment of congestive heart failure. Seven months after starting the captopril therapy he developed flaccid vesiculobullae and erythematous patches with oozing, crusted surfaces on his trunk and the proximal portion of his extremities. The mucous membranes were not involved. The mucous membranes were not involved.) The histopathologic findings showed subcorneal bulla containing a few acantholytic cells and direct immunofluorescent studies revealed intercellular deposition of IgG and C3 throughout entire epidermis, consistent with pemphigus foliaceus. After captopril therapy was discontinued, the skin lesions gradually improved within 1 month. Pemphigus foliaceus; is a rare complication of captopril therapy and this is, to our knowledge, the first case report in Korea.
