Effects of M-VAC(Methotrexate, Vinblastine, Doxorubicin and Cisplatin) Regimen on Experimental Animal: Histopathological Study.
- Author:
Sun Jin KIM
1
;
Wun Jae KIM
;
Young Kyoon KIM
Author Information
1. Department of Urology, College of Medicine, Seoul National University, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
M-VAC;
bladder cancer
- MeSH:
Animals*;
Doxorubicin*;
Incidence;
Kidney;
Polycystic Kidney Diseases;
Ultrasonography;
Urinary Bladder Neoplasms;
Vinblastine*
- From:Korean Journal of Urology
1990;31(1):14-22
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Histopathologic study was performed to observe the effects of M-VAC (methotrexate, vinblastine, doxorubicin and cisplatin), widely used for advanced bladder cancer and its metastatic lesion, on the visceral organs of the experimental animal. M-VAC was used intraperitoneally throughout the study and the following results were obtained : 1. There were severe adhesions of visceral organs in all of experimental groups, compared with the control group. 2. Compared with the control group(15.0%), significant increase of incidence in renal cystic changes in experimental group(89.6%) was observed. The lesions were similar to polycystic kidney type I and considered to be irreversible. Therefore, ultrasonography of the kidney during the M-VAC regimen may be clinically worthwhile. 3. Portal triaditis ( 27.5% ) and fatty metamorphosis of the liver(24.1%) were observed significantly in the experimental group but they were limited, localized changes and thought to be reversible. Deterioration in hepatic function may not be seriously considered.
