Clinical Features and Outcomes of Invasive Intraductal Papillary Mucinous Neoplasm: Comparison with Pancreatic Ductal Adenocarcinoma.
- Author:
Kwang Yeol PAIK
1
;
Jun Chul JUNG
;
Jin Seok HEO
;
Seong Ho CHOI
;
Dong Wook CHOI
;
Yong Il KIM
Author Information
1. Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. gsshchoi@smc.samsung.co.kr
- Publication Type:Original Article
- Keywords:
Invasive;
Intraductal papillary mucinous neoplasm (IPMN);
Carcinoma in-situ (CIS);
Pancreatic ductal adenocarcinoma;
Well differentiated
- MeSH:
Adenocarcinoma*;
Adenoma;
Bilirubin;
Humans;
Hyperplasia;
Mucins*;
Pancreatic Ducts*;
Prognosis;
Retrospective Studies;
Survival Rate
- From:Journal of the Korean Surgical Society
2007;72(4):270-275
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: Histologically, IPMN (intraductal papillary mucinous neoplasm) includes various grades of lesion, from hyperplasia and adenoma to adenocarcinoma. The prognosis is different for each histological grade. The malignant IPMN contain in-situ and invasive carcinoma. The purpose of this study was to investigate the clinicopathologic features and outcome of invasive IPMN. METHODS: 18 patients with invasive IPMN underwent surgical treatment between October 1994 and December 2005 at Samsung Medical Center. The clinical, biochemical and pathologic features were retrospectively analyzed. Survival and the clinicopathologic features were compared between invasive IPMN and PDAC of the well differentiated type (wd, n=27) and carcinoma in-situ (CIS, n=10). RESULTS: The preoperative CA19-9 level and total bilirubin level of invasive IPMN patients was statistically higher than those of the CIS patients. The tumor size of invasive IPMN was larger than that of PDAC (wd) (P=0.038). The median survival of patients with invasive IPMN was 31.0 month. The 5-year survival rates of patients with PDAC (wd) and invasive IPMN were 35.5% and 41.7%, respectively (P= 0.237). CONCLUSION: there were no differences for invasive IPMN and PDAC (wd) except for tumor size. The survival in patients with surgical resected invasive IPMN was similar to that of the patients with surgical resected PDAC (wd).
