Retrospective Analysis of ADR in Elderly Patients in Sichuan Province during 2013-2019
- VernacularTitle:2013－2019年四川省老年患者药品不良反应的回顾性分析
- Author:
Linke ZOU
1
;
Junfeng YAN
1
,
2
;
Shan LAN
3
;
Chengyun WU
3
;
Jing LIU
1
;
Xingwei WU
1
,
2
;
Yuan BIAN
1
,
2
;
Shan DU
1
Author Information
1. College of Medicine，University of Electronic Science and Technology of China，Chengdu 610072，China
2. Sichuan Key Lab of Individualized Drug Therapy，Dept. of Pharmacy，Sichuan Academy of Medical Sciences/ Sichuan People’s Hospital/the Affiliated Hospital of University of Electronic Science and Technology of China，Chengdu 610072，China
3. Sichuan Provincial ADR Monitoring Center，Chengdu 610041，China
- Publication Type:Journal Article
- Keywords:
Sichuan province;
Adverse drug reactions;
Elderly patients;
Retrospective analysis
- From:
China Pharmacy
2020;31(22):2757-2762
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE：To investigate the situ ation and characteristics of ADR reports in the elderly patients （≥65 years old ） of Sichuan province ，and to provide reference for guaranteeing the safety of drug use. METHODS ：ADR reporting data of elderly patients collected by spontaneous reporting system of Sichuan ADR monitoring center from 2013 to 2019 were collected ，and then analyzed in respects of report types ，reproting institution ，relationship，patienst’age，gender，nationality，drug type ，organ/system invovled. RESULTS & CONCLUSIONS ：In the past seven years ，175 431 cases spontaneous ADR were collected by Sichuan ADR monitoring center ，and the annual proportion of “general”ADR reports decreased from 78.93％ in 2013 to 60.50％ year by year ； the annual proportion of “new general ”and“serious”ADRs increased year by year ，among which that of “new general ”ADR increased more obviously. The main reporting institutions were medical institutions ，accounting for 92.79％-98.87％ of the total annual reports. The enthusiasm of enterprises and individuals to report ADR needed to be improved ；8 031 cases（4.58％）were “positive”relationship，21 283 cases（12.13％）were“likely”，146 117 cases（83.29％）were“possible”. Except that the gender of 272 cases were not reported ，there were 88 176 male cases and 86 983 female cases ；most of them were 65-74 years old （104 962 cases，59.83％）. The reports covered 19 nationalities，among which the re were 166 752 cases（98.72％）of Han nationality. The distribution of ADR related drug categories in elderly patients of Yi ， Tibetan and Qiang nationalities was significantly different from that of Han nationality （P＜0.01）. The top three drug categories in the total frequency were anti-infective drugs （31.10％），traditional Chinese medicine com （18.27％），and central nervous system drugs （9.99％）. The injection route was the most likely to cause ADR （72.12％）. ADR mainly involved s kin and its appendants （21.47％）， gastrointestinal system （19.61％）and central and peripheral nervous system （18.55％）. Aminophylline injection was the only dr ug in the top 10 drugs leading to “new general ”ADR for consecutive 7 years. Cefotaxime sodium for injection ，Ceftriaxone sodium for injection ，Cefoperazone sodium and sulbactam sodium for injection were the top 10 drugs causing “severe”ADR in consecutive 7 years，which should be paid more attention in clinic.
