Preparation and preliminary evaluation of ribavirin liposome-powder inhaler
10.12206/j.issn.1006-0111.202004077
- VernacularTitle:利巴韦林脂质体吸入粉雾剂的研制与初步评价
- Author:
Xiaqin FANG
1
;
Huajin TAN
1
;
Xiaochuan TAN
1
;
He LI
1
;
Yujia ZHANG
1
;
Wensheng ZHENG
1
Author Information
1. Beijing City Key laboratory of Drug Delivery Technology and Novel Formulation, Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing 100050, China.
- Keywords:
ribavirin;
liposomal;
lyophilized;
powder inhalers
- From:
Journal of Pharmaceutical Practice
2020;38(6):539-542
- CountryChina
- Language:Chinese
-
Abstract:
Objective In order to solve the obvious adverse reactions of ribavirin, to develop ribavirin liposome inhalation powder and to evaluate its quality characteristics. Methods The ribavirin liposomes were prepared by the thin film dispersion method, and then lyophilized to prepare ribavirin liposome powder. The appearance, fluidity, bulk density, encapsulation efficiency, particle size of the complex solution, PDI, potential and hydrophilicity were examined. Results Ribavirin liposome powder has good morphology, particle size, potential, fluidity and hydrophilicity, which can meet the basic requirements of powder medicine for drug administration. Conclusion The technique of preparing ribavirin liposome powder aerosol preparation by this method is feasible, and it provides the basic technology for future in vivo and in vitro studies.
