Study on the anti-inflammatory and analgesic effects of active fractions of Tongfeng granule on arthritis rats
10.12206/j.issn.1006-0111.202007015
- VernacularTitle:痛风颗粒各有效部位群对关节炎大鼠的抗炎镇痛作用研究
- Author:
Yi XU
1
;
Jing LIU
1
;
Jin HUANG
1
;
Jingang CUI
2
;
Tiejun WU
1
Author Information
1. Department. of Pharmacy, Yueyang Hospital of Integrated Traditional and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China.
2. Clinical Research Institute of Integrative Medicine, Shanghai Academy of Traditional Chinese Medicine, Shanghai 200437, China.
- Keywords:
gout granule;
active fractions;
anti-inflammation;
analgesia
- From:
Journal of Pharmaceutical Practice
2020;38(6):528-532
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the anti-inflammatory and analgesic effects of the active fractions of Tongfeng granules on rats with arthritis induced by complete Freund's adjuvant. Methods 56 SD rats were randomly divided into seven groups, blank group, model group, total flavonoids group, total organic acid group, total alkaloid group, Tongfeng granule group and positive control group. Except for the blank group, the remaining 6 groups established joints pathological model of inflammation. 15 days after the successful modeling, intragastric drug administration was continued for 30 days. The swelling of ankle joint, WBC, N%, IL-6, IL-10, TNF-α and the histopathology of joint were measured. Results Comparing with the model group, each effective fraction group of Tongfeng granules, Gout granules and positive control group decreased the ankle joint swelling rate significantly (P<0.01) and reduced fibrous tissue proliferation. There was no significant difference in WBC and N% of neutrophils. They significantly reduce the level of serum IL-6 and TNF-α, and increase the level of IL-10 (P<0.05, P<0.01). Conclusion This study clarifies the anti-inflammatory and analgesic effects of active fractions of Tongfeng granules and provides a basis for further clinical medication and preparation development.
