Acute Necrotizing Encephalopathy of Childhood: A Severe Case with Fatal Outcome

Author: Yee Lin Lee ¹ ; Hasyma Abu Hassan ² ; Intan Hakimah Ismail ¹
Author Information

1. Department of Paediatrics, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 434000, Serdang, Selangor, Malaysia
2. Department of Imaging, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 434000, Serdang, Selangor, Malaysia
Publication Type:Case Reports
Keywords: Acute encephalopathy, Acute necrotizing encephalopathy of childhood, Methylprednisolone
From:Malaysian Journal of Medicine and Health Sciences 2020;16(No.2):323-325
CountryMalaysia
Language:English
Abstract: Acute necrotizing encephalopathy of childhood (ANEC) is a rare condition which is important for clinicians to recognize as it has a high mortality rate and can result in significant neurological morbidities. It presents as acute encephalopathy with radiological findings of symmetrical brain lesions in bilateral thalami, putamen, brain stem tegmentum, internal capsule, periventricular white matter and cerebellar medulla. Intravenous methylprednisolone is the mainstay of treatment. Immunoglobulin therapy and therapeutic hypothermia may be used as adjunctive therapy in cases with severe clinical and neuroradiological presentation. We present a case of severe ANEC and discuss the clinical manifestations, neuroimaging and management options.
Full text:11.2020my0686.pdf