Crohn's Disease Associated with IgA Nephropathy.
- Author:
Ji Youn YOUM
1
;
Oh Young LEE
;
Moon Hyang PARK
;
Sun Young YANG
;
Sung Hee HAN
;
Yoo Hum BAEK
;
Song Ree PARK
;
Hang Lack LEE
;
Byoung Chul YOON
;
Ho Soon CHOI
;
Joon Soo HAHM
;
Min Ho LEE
;
Dong Hoo LEE
;
Chun Suk KEE
Author Information
1. Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea. leeoy@hanyang.ac.kr
- Publication Type:Case Report ; English Abstract
- Keywords:
Crohns disease;
IgA nephropathy
- MeSH:
Adult;
Crohn Disease/*complications/pathology;
Glomerulonephritis, IGA/*complications/pathology;
Humans;
Male
- From:The Korean Journal of Gastroenterology
2006;47(4):324-328
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Crohn's disease is a condition of chronic inflammation potentially involving any location of the alimentary tract from mouth to anus. Numerous extraintestinal manifestations can also be present. Urologic complications of inflammatory bowel disease are seen in up to 25% of patients, but renal parenchymal disease has been rarely reported. IgA nephropathy is recognized worldwide as a most common form of primary glomerulonephritis. Clinical manifestations vary, ranging from microscopic hematuria to nephrotic syndrome. Recently, IgA nephropathy associated with systemic diseases has been reported. We describe a case of a 22 year-old man with Crohn's disease associated with IgA nephropathy. At the age of 8 years, microscopic hematuria appeared. After fourteen years, he presented with melena, mild fever, recurrent oral ulcer, microscopic hematuria and proteinuria. Colonoscopic examination revealed characteristic features of Crohn's disease such as multiple ulcers. Microscopic findings showed superficial ulceration with small noncaseating granulomas. Renal biopsy revealed IgA nephropathy. The patient was treated with oral prednisolone, olsalazine, and metronidazole followed by maintenance therapy with sulfasalazine and azathioprine resulting in clinical improvement of Crohn's disease and IgA nephropathy.
