Expression and role of matrix metalloproteinase in injury related renal transplantation
10.3969/j.issn.1674-7445.2020.06.018
- VernacularTitle:基质金属蛋白酶在肾移植相关损伤中的表达及作用
- Author:
Yan DONG
1
;
Hong ZHAO
;
Jiangwei MAN
;
Li YANG
Author Information
1. Department of Urology, Lanzhou University Second Hospital, Lanzhou 730030, China
- Publication Type:Research Article
- Keywords:
Matrix metalloproteinase;
Renal transplantation;
Extracellular matrix;
Tissue inhibitor of metalloprotease;
Acute kidney injury;
Ischemia-reperfusion injury;
Chronic allograft nephropathy;
Inflammation
- From:
Organ Transplantation
2020;11(6):760-
- CountryChina
- Language:Chinese
-
Abstract:
Matrix metalloproteinase (MMP) is a large class of proteases which can cut or reshape extracellular matrix (ECM) and cell surface proteins. The activity of MMP is regulated by a variety of cytokines, including tissue inhibitor of metalloprotease (TIMP), signal transduction molecules and cell adhesion molecules. The latest research shows that MMP has a role in the pathophysiology process of many acute and chronic kidney diseases. In this article, the classification, expression and distribution in the kidney of MMP and its role in injury related renal transplantation was reviewed.
