Research progress on the application of liver transplantation in HIV combined with HCV positive patients
10.3969/j.issn.1674-7445.2020.06.005
- VernacularTitle:肝移植治疗HIV合并HCV阳性患者的研究进展
- Author:
Xijing YAN
1
;
Yang YANG
Author Information
1. Department of Hepatic Surgery, Liver Transplantation Center, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China
- Publication Type:Research Article
- Keywords:
Liver transplantation;
Hepatitis C virus (HCV);
Human immunodeficiency virus (HIV);
Acquired immune deficiency syndrome (AIDS);
Highly active antiretroviral therapy;
End-stage liver disease;
Viral hepatitis C recurrence;
Direct antiviral agent
- From:
Organ Transplantation
2020;11(6):677-
- CountryChina
- Language:Chinese
-
Abstract:
With the advent of highly active antiretroviral therapy (HAART), acquired immune deficiency syndrome (AIDS) has gradually evolved from an incurable terminal disease to a controllable chronic disease. Due to the extended survival of AIDS patients, chronic renal failure and (or) chronic liver failure have become the main cause of death, and AIDS patients with chronic liver failure are constantly complicated with hepatitis C virus (HCV) infection. Human immunodeficiency virus (HIV) infection was previously considered as a contraindication for liver transplantation. With the deepening of medical cognition and improvement of surgical management experience, the quantity of HIV positive liver transplantation recipients has been steadily elevated and high long-term survival rate has been achieved. Nevertheless, the 3-, 5-, and 10-year survival rates after liver transplantation of HIV combined with HCV positive patients remain extremely low. In this article, the development of liver transplantation in HIV positive patients, the disease progression of HIV combined with HCV positive patients, and the treatment for the recurrence of viral hepatitis C after the operation were summarized.
